@import url('https://fonts.googleapis.com/css2?family=Instrument+Sans:wght@400;500;600;700&family=Noto+Sans+JP:wght@300;400;500;600;700;900&display=swap');

:root{
  --bk:#000;--bk-light:#222;--gr:#888;--gr-light:#bbb;--gr-pale:#f5f5f5;
  --coral:#E8584F;--coral-h:#D04A42;--coral-pale:#FEF2F1;
  --wh:#fff;--off:#fafafa;--rule:#e0e0e0;--rule-dark:#000;
  --hd:'Instrument Sans','Noto Sans JP',sans-serif;
  --bd:'Noto Sans JP',sans-serif;
  --mw:1060px;--hh:56px;
}
*,*::before,*::after{margin:0;padding:0;box-sizing:border-box}
html{scroll-behavior:smooth;-webkit-text-size-adjust:100%}
body{font-family:var(--bd);font-weight:400;color:var(--bk);background:var(--wh);line-height:1.85;font-size:14px;-webkit-font-smoothing:antialiased;overflow-x:hidden}
img{max-width:100%;display:block}a{text-decoration:none;color:inherit;transition:color .2s}ul,ol{list-style:none}table{border-collapse:collapse;width:100%}

.w{max-width:var(--mw);margin:0 auto;padding:0 24px}
.lbl{font-family:var(--hd);font-size:10px;font-weight:600;letter-spacing:.3em;text-transform:uppercase;color:var(--gr);margin-bottom:6px}
.ttl{font-size:26px;font-weight:700;color:var(--bk);line-height:1.35;margin-bottom:10px}
.dsc{font-size:13px;color:var(--gr);line-height:1.85;max-width:520px}
.hd-c{text-align:center;margin-bottom:48px}.hd-c .dsc{margin:0 auto}
.ph{border:1px solid var(--rule);display:flex;align-items:center;justify-content:center;color:var(--gr-light);font-size:12px;font-weight:500;background:var(--off)}

.rv{opacity:0;transform:translateY(16px);transition:opacity .55s cubic-bezier(.22,1,.36,1),transform .55s cubic-bezier(.22,1,.36,1)}.rv.vis{opacity:1;transform:none}

/* ===== HEADER ===== */
.hdr{position:fixed;top:0;left:0;right:0;height:var(--hh);background:var(--wh);border-bottom:1px solid var(--rule);z-index:1000;transition:box-shadow .3s}
.hdr.scrolled{box-shadow:0 1px 8px rgba(0,0,0,.04)}
.hdr-in{max-width:var(--mw);margin:0 auto;padding:0 24px;height:100%;display:flex;align-items:center;justify-content:space-between}
.logo{display:flex;align-items:baseline;gap:6px}
.logo-m{font-family:var(--hd);font-size:20px;font-weight:700;color:var(--bk)}
.logo-t{font-size:11px;font-weight:500;color:var(--gr)}
.nav-d{display:flex;align-items:center;gap:24px}
.nav-d a{font-size:12px;font-weight:500;color:var(--gr);transition:color .2s}
.nav-d a:hover,.nav-d a.on{color:var(--bk)}
.hdr-cta{font-size:11px;font-weight:600;color:var(--coral);border:1.5px solid var(--coral);padding:7px 16px;border-radius:4px;transition:background .2s,color .2s}
.hdr-cta:hover{background:var(--coral);color:var(--wh)}
.ham{display:none;flex-direction:column;gap:5px;width:22px;cursor:pointer;background:none;border:none;padding:0}
.ham span{display:block;width:100%;height:1.5px;background:var(--bk);transition:transform .3s,opacity .3s}
.ham.open span:nth-child(1){transform:translateY(6.5px) rotate(45deg)}.ham.open span:nth-child(2){opacity:0}.ham.open span:nth-child(3){transform:translateY(-6.5px) rotate(-45deg)}
.nav-m{display:none;position:fixed;top:var(--hh);left:0;right:0;bottom:0;background:var(--wh);z-index:999;padding:32px 24px;overflow-y:auto}
.nav-m.open{display:block}
.nav-m a{display:block;padding:14px 0;font-size:16px;font-weight:500;color:var(--bk);border-bottom:1px solid var(--rule)}
.nav-m .m-cta{display:block;text-align:center;margin-top:20px;color:var(--coral);font-weight:600;padding:14px;border:1.5px solid var(--coral);border-radius:6px}

/* ===== HERO: 60/40 asymmetric ===== */
.hero{padding:calc(var(--hh) + 48px) 0 0}
.hero-split{display:grid;grid-template-columns:3fr 2fr;gap:32px;align-items:center}
.hero-tags{display:flex;gap:6px;flex-wrap:wrap;margin-bottom:16px}
.hero-tag{font-size:10px;font-weight:600;color:var(--coral);letter-spacing:.06em}
.hero-tag:not(:last-child)::after{content:'|';margin-left:6px;color:var(--rule)}
.hero h1{font-size:42px;font-weight:900;color:var(--bk);line-height:1.25;margin-bottom:16px;letter-spacing:-.02em}
.hero-sub{font-size:13px;color:var(--gr);line-height:1.85;margin-bottom:28px}
.hero-photo .ph{width:100%;aspect-ratio:3/4;border-radius:4px}
.hero-stats{border-top:1px solid var(--rule);border-bottom:1px solid var(--rule);padding:16px 0;margin-top:40px;font-size:12px;color:var(--gr);display:flex;gap:32px;align-items:center}
.hero-stats strong{font-family:var(--hd);font-size:18px;font-weight:700;color:var(--bk);margin-right:4px}
.hero-note{font-size:10px;color:var(--gr-light);margin-top:10px}

/* ===== CTA BUTTON ===== */
.btn{display:inline-flex;align-items:center;gap:6px;background:transparent;color:var(--coral);font-family:var(--bd);font-size:14px;font-weight:700;padding:13px 28px;border-radius:4px;border:2px solid var(--coral);cursor:pointer;transition:background .2s,color .2s,transform .15s}
.btn:hover{background:var(--coral);color:var(--wh);transform:translateY(-1px)}

/* ===== FLOATING CTA: bottom banner ===== */
.fl-bar{position:fixed;bottom:0;left:0;right:0;z-index:900;background:var(--wh);border-top:1px solid var(--rule);padding:10px 24px;display:flex;align-items:center;justify-content:space-between;opacity:0;transform:translateY(100%);pointer-events:none;transition:opacity .3s,transform .3s}
.fl-bar.vis{opacity:1;transform:none;pointer-events:auto}
.fl-bar p{font-size:12px;color:var(--gr)}
.fl-bar .btn{font-size:12px;padding:8px 20px}

/* ===== SUBJECTS: numbered strips ===== */
.subj{padding:72px 0}
.subj-list{border-top:1px solid var(--rule-dark)}
.subj-strip{display:grid;grid-template-columns:60px 1fr auto;gap:24px;align-items:center;padding:28px 0;border-bottom:1px solid var(--rule);transition:background .15s}
.subj-strip:hover{background:var(--gr-pale)}
.subj-num{font-family:var(--hd);font-size:32px;font-weight:700;color:var(--rule);line-height:1}
.subj-body h3{font-size:18px;font-weight:700;color:var(--bk);margin-bottom:4px}
.subj-body p{font-size:12px;color:var(--gr);line-height:1.7}
.subj-arrow{font-size:12px;font-weight:600;color:var(--coral);display:flex;align-items:center;gap:4px;white-space:nowrap;transition:gap .2s}
.subj-strip:hover .subj-arrow{gap:8px}

/* ===== REASONS: 2x2 grid ===== */
.reasons{padding:72px 0;background:var(--off);border-top:1px solid var(--rule);border-bottom:1px solid var(--rule)}
.rsn-grid{display:grid;grid-template-columns:1fr 1fr;gap:0}
.rsn-cell{padding:32px 28px;border-top:3px solid var(--bk);border-right:1px solid var(--rule);border-bottom:1px solid var(--rule)}
.rsn-cell:nth-child(2n){border-right:none}
.rsn-cell:nth-child(n+3){border-top:none}
.rsn-n{font-family:var(--hd);font-size:11px;font-weight:600;color:var(--gr-light);margin-bottom:8px}
.rsn-cell h3{font-size:18px;font-weight:700;color:var(--bk);margin-bottom:6px;line-height:1.35}
.rsn-cell p{font-size:12px;color:var(--gr);line-height:1.7}

/* ===== FLOW: horizontal with dividers ===== */
.flow-sec{padding:72px 0}
.flow-row{display:flex;border-top:1px solid var(--rule-dark);border-bottom:1px solid var(--rule)}
.fl-step{flex:1;padding:28px 20px;border-right:1px solid var(--rule);position:relative}
.fl-step:last-child{border-right:none}
.fl-n{font-family:var(--hd);font-size:48px;font-weight:700;color:var(--gr-pale);line-height:1;margin-bottom:8px}
.fl-step h3{font-size:14px;font-weight:700;color:var(--bk);margin-bottom:2px}
.fl-time{font-size:10px;font-weight:600;color:var(--coral);margin-bottom:6px}
.fl-step>p{font-size:11px;color:var(--gr);line-height:1.6}

/* ===== VOICE: asymmetric 2-col ===== */
.voice{padding:72px 0;background:var(--off);border-top:1px solid var(--rule);border-bottom:1px solid var(--rule)}
.voice-grid{display:grid;grid-template-columns:1fr 1fr;gap:0;border-top:1px solid var(--rule-dark)}
.v-main{padding:32px 28px 32px 0;border-right:1px solid var(--rule)}
.v-side{display:flex;flex-direction:column}
.v-side-item{padding:24px 0 24px 28px;flex:1}
.v-side-item:first-child{border-bottom:1px solid var(--rule)}
.v-top{display:flex;align-items:center;gap:12px;margin-bottom:12px}
.v-av{width:40px;height:40px;border-radius:50%;flex-shrink:0;font-size:8px}
.v-meta h4{font-size:13px;font-weight:700;color:var(--bk)}
.v-meta span{font-size:10px;color:var(--gr)}
.v-tag{font-size:10px;font-weight:600;color:var(--coral);margin-bottom:8px;display:inline-block}
.v-text{font-size:12px;color:var(--gr);line-height:1.8}

/* ===== FAQ ===== */
.faq-sec{padding:72px 0}
.faq-list{border-top:1px solid var(--rule-dark)}
.fq{border-bottom:1px solid var(--rule)}
.fq-q{width:100%;background:none;border:none;padding:20px 0;display:flex;align-items:flex-start;justify-content:space-between;gap:12px;cursor:pointer;text-align:left;font-family:var(--bd);font-size:14px;font-weight:600;color:var(--bk);line-height:1.6}
.fq-tog{flex-shrink:0;width:20px;height:20px;position:relative;margin-top:2px}
.fq-tog::before,.fq-tog::after{content:'';position:absolute;top:50%;left:50%;background:var(--gr-light);transition:transform .3s}
.fq-tog::before{width:10px;height:1.5px;transform:translate(-50%,-50%)}
.fq-tog::after{width:1.5px;height:10px;transform:translate(-50%,-50%)}
.fq.open .fq-tog::after{transform:translate(-50%,-50%) rotate(90deg)}
.fq-a{max-height:0;overflow:hidden;transition:max-height .4s cubic-bezier(.22,1,.36,1)}
.fq-a-in{padding:0 0 20px 0;display:flex;gap:10px;align-items:flex-start}
.fq-a-mark{flex-shrink:0;font-family:var(--hd);font-size:13px;font-weight:700;color:var(--coral);width:20px}
.fq-a-text{font-size:13px;color:var(--gr);line-height:1.85}

/* ===== CTA BAND: text link style ===== */
.cta-band{padding:56px 0;background:var(--bk);text-align:center}
.cta-band h2{font-size:20px;font-weight:700;color:var(--wh);margin-bottom:4px}
.cta-band p{font-size:12px;color:rgba(255,255,255,.4);margin-bottom:24px}
.cta-link{font-size:16px;font-weight:700;color:var(--coral);border-bottom:2px solid var(--coral);padding-bottom:2px;transition:color .2s,border-color .2s;display:inline-block}
.cta-link:hover{color:#ff7b73;border-color:#ff7b73}

/* ===== FOOTER: single row ===== */
.ftr{background:var(--bk);color:var(--wh);padding:40px 0 0}
.ftr-row{display:flex;align-items:flex-start;justify-content:space-between;gap:32px;padding-bottom:32px;border-bottom:1px solid rgba(255,255,255,.08)}
.ftr-logo{flex-shrink:0}
.ftr-logo .logo-m{color:var(--wh)}.ftr-logo .logo-t{color:rgba(255,255,255,.4)}
.ftr-nav{display:flex;gap:20px}
.ftr-nav a{font-size:11px;color:rgba(255,255,255,.5);transition:color .2s}
.ftr-nav a:hover{color:var(--wh)}
.ftr-info{text-align:right;font-size:11px;color:rgba(255,255,255,.4);line-height:1.7}
.ftr-map{margin-top:32px;padding-bottom:32px;border-bottom:1px solid rgba(255,255,255,.08)}
.ftr-map iframe{width:100%;height:180px;border:none;border-radius:4px}
.ftr-btm{padding:16px 0;display:flex;justify-content:space-between;font-size:10px;color:rgba(255,255,255,.25)}
.ftr-legal{font-size:9px;color:rgba(255,255,255,.3);line-height:1.8;padding:20px 0;border-top:1px solid rgba(255,255,255,.08)}

/* ===== BREADCRUMB ===== */
.bc{padding:calc(var(--hh) + 12px) 0 0;font-size:11px;color:var(--gr)}
.bc a{color:var(--gr)}.bc a:hover{color:var(--bk)}
.bc span{margin:0 6px;color:var(--rule)}

/* ===== SUB HERO: left-aligned 70/30 ===== */
.sub-hero{padding:32px 0 48px;border-bottom:1px solid var(--rule)}
.sub-hero-split{display:grid;grid-template-columns:7fr 3fr;gap:32px;align-items:start}
.sub-hero .hero-tags{margin-bottom:12px}
.sub-hero h1{font-size:32px;font-weight:900;color:var(--bk);line-height:1.3;margin-bottom:10px}
.sub-hero-desc{font-size:13px;color:var(--gr);line-height:1.85;margin-bottom:24px}
.sub-hero-note{font-size:10px;color:var(--gr-light);margin-top:10px}
.sub-hero-photo .ph{width:100%;aspect-ratio:3/4;border-radius:4px}

/* ===== CONCERNS ===== */
.concerns{padding:64px 0}
.con-list{max-width:600px;margin:0 auto;border-top:1px solid var(--rule)}
.con{display:flex;align-items:flex-start;gap:10px;padding:14px 0;border-bottom:1px solid var(--rule)}
.con-chk{flex-shrink:0;width:18px;height:18px;border:1.5px solid var(--coral);border-radius:2px;display:flex;align-items:center;justify-content:center;margin-top:2px}
.con-chk svg{width:10px;height:10px;stroke:var(--coral);fill:none;stroke-width:2.5}
.con p{font-size:13px;color:var(--bk);font-weight:500}

/* ===== ABOUT DISEASE ===== */
.about-d{padding:64px 0;background:var(--off);border-top:1px solid var(--rule);border-bottom:1px solid var(--rule)}
.about-d-in{display:grid;grid-template-columns:1fr 1fr;gap:36px;align-items:start}
.about-d-txt h3{font-size:18px;font-weight:700;color:var(--bk);margin-bottom:12px}
.about-d-txt p{font-size:13px;color:var(--gr);line-height:1.9;margin-bottom:10px}

/* ===== PRICING: alternating rows ===== */
.pricing{padding:72px 0}
.pr-header{display:flex;justify-content:space-between;align-items:flex-end;margin-bottom:4px;padding-bottom:12px;border-bottom:2px solid var(--bk)}
.pr-info{display:flex;gap:12px;font-size:11px;color:var(--gr)}
.pr-info strong{color:var(--coral);font-weight:700}
.pr-labels{display:grid;grid-template-columns:180px 1fr 140px 1fr;gap:12px;padding:10px 12px;font-size:10px;font-weight:600;color:var(--gr);text-transform:uppercase;letter-spacing:.05em}
.pr-row{display:grid;grid-template-columns:180px 1fr 140px 1fr;gap:12px;padding:16px 12px;align-items:center;font-size:13px}
.pr-row:nth-child(odd){background:var(--gr-pale)}
.pr-name{font-weight:700;color:var(--bk)}
.pr-drug{font-size:11px;color:var(--gr);margin-top:1px}
.pr-val{font-family:var(--hd);font-size:18px;font-weight:700;color:var(--bk)}
.pr-val small{font-size:11px;font-weight:500}
.pr-sub{font-size:10px;color:var(--gr)}
.pr-for{font-size:11px;color:var(--gr)}
.pr-note{font-size:10px;color:var(--gr-light);margin-top:12px;line-height:1.7}

/* ===== CASES: full-width rows ===== */
.cases{padding:64px 0;background:var(--off);border-top:1px solid var(--rule);border-bottom:1px solid var(--rule)}
.case-list{border-top:1px solid var(--bk)}
.case-row{display:flex;gap:24px;padding:28px 0;border-bottom:1px solid var(--rule);align-items:center}
.case-imgs{display:flex;gap:8px;flex-shrink:0}
.case-w{position:relative;width:140px;height:140px}
.case-w img{width:100%;height:100%;object-fit:cover;border-radius:3px}
.case-w span{position:absolute;top:4px;left:4px;font-family:var(--hd);font-size:9px;font-weight:700;color:var(--wh);background:rgba(0,0,0,.6);padding:2px 6px;border-radius:2px;letter-spacing:.04em}
.case-info h4{font-size:14px;font-weight:700;color:var(--bk);margin-bottom:4px}
.case-info p{font-size:11px;color:var(--gr);line-height:1.6}

/* ===== DRUG COMPARE ===== */
.drug-cmp{padding:64px 0}
.cmp-tbl{border-radius:8px;overflow:hidden;border:1px solid var(--rule)}
.cmp-tbl th,.cmp-tbl td{padding:12px 14px;text-align:center;font-size:12px;border-bottom:1px solid var(--rule)}
.cmp-tbl thead th{background:var(--bk);color:var(--wh);font-weight:600;font-size:11px;border-bottom:none}
.cmp-tbl tbody th{background:var(--gr-pale);font-weight:600;color:var(--bk);text-align:left;font-size:11px}
.cmp-tbl tbody td{color:var(--gr)}
.cmp-hl{background:var(--coral-pale) !important;font-weight:600;color:var(--bk) !important}

/* ===== TRIAL: numbered items ===== */
.trial{padding:64px 0;background:var(--off);border-top:1px solid var(--rule);border-bottom:1px solid var(--rule)}
.trial-list{border-top:1px solid var(--bk)}
.trial-item{display:grid;grid-template-columns:48px 1fr;gap:16px;padding:24px 0;border-bottom:1px solid var(--rule);align-items:start}
.trial-num{font-family:var(--hd);font-size:24px;font-weight:700;color:var(--rule)}
.trial-body h3{font-size:15px;font-weight:700;color:var(--bk);margin-bottom:4px}
.trial-body p{font-size:12px;color:var(--gr);line-height:1.7;margin-bottom:8px}
.trial-pr{font-family:var(--hd);font-size:20px;font-weight:700;color:var(--bk)}
.trial-pr small{font-size:11px;font-weight:500}
.trial-drg{font-size:10px;color:var(--gr);margin-top:8px;padding-top:8px;border-top:1px solid var(--rule);line-height:1.6}

/* ===== GLP-1: tabs ===== */
.glp{padding:64px 0}
.glp-tabs{display:flex;gap:0;border-bottom:2px solid var(--bk);margin-bottom:32px}
.glp-tab{padding:10px 28px;font-size:13px;font-weight:600;color:var(--gr);cursor:pointer;background:none;border:none;border-bottom:2px solid transparent;margin-bottom:-2px;transition:color .2s,border-color .2s;font-family:var(--bd)}
.glp-tab.active{color:var(--bk);border-bottom-color:var(--coral)}
.glp-panel{display:none}.glp-panel.active{display:block}
.glp-item{padding:24px 0;border-bottom:1px solid var(--rule)}
.glp-item:first-child{border-top:1px solid var(--rule)}
.glp-tg{display:inline-block;font-size:9px;font-weight:600;color:var(--coral);border:1px solid var(--coral);padding:2px 7px;border-radius:2px;margin-bottom:8px}
.glp-item h3{font-size:16px;font-weight:700;color:var(--bk);margin-bottom:6px}
.glp-item>p{font-size:12px;color:var(--gr);line-height:1.8;margin-bottom:10px;max-width:600px}
.glp-dl{font-size:12px}.glp-dl dt{font-weight:700;color:var(--bk);margin-bottom:2px}.glp-dl dd{color:var(--gr);margin-bottom:8px;padding-left:12px;border-left:2px solid var(--rule)}

/* ===== REASONS COMPACT ===== */
.rsn-c{padding:64px 0;background:var(--off);border-top:1px solid var(--rule);border-bottom:1px solid var(--rule)}

/* ===== LEGAL ===== */
.legal{padding:32px 0;border-top:1px solid var(--rule)}
.legal h4{font-size:10px;font-weight:600;color:var(--gr);margin-bottom:6px}
.legal p{font-size:9px;color:var(--gr-light);line-height:1.8}

/* ===== RESPONSIVE ===== */
@media(max-width:768px){
  :root{--hh:50px}
  .nav-d,.hdr-cta{display:none}.ham{display:flex}
  .hero h1{font-size:28px}
  .hero-split,.sub-hero-split{grid-template-columns:1fr}
  .hero-photo{order:-1;max-width:280px}
  .hero-stats{flex-wrap:wrap;gap:16px}
  .sub-hero-photo{order:-1;max-width:200px}
  .subj-strip{grid-template-columns:40px 1fr;gap:12px}
  .subj-arrow{display:none}
  .rsn-grid{grid-template-columns:1fr}
  .rsn-cell{border-right:none}
  .rsn-cell:nth-child(n+2){border-top:none}
  .flow-row{flex-direction:column}
  .fl-step{border-right:none;border-bottom:1px solid var(--rule)}
  .fl-step:last-child{border-bottom:none}
  .voice-grid{grid-template-columns:1fr}
  .v-main{border-right:none;padding-right:0;border-bottom:1px solid var(--rule);padding-bottom:24px}
  .v-side-item{padding-left:0}
  .ftr-row{flex-direction:column;gap:20px}
  .ftr-info{text-align:left}
  .ftr-btm{flex-direction:column;gap:4px}
  .about-d-in{grid-template-columns:1fr}
  .pr-labels{display:none}
  .pr-row{grid-template-columns:1fr;gap:4px}
  .case-row{flex-direction:column}
  .case-imgs{width:100%}
  .case-w{width:calc(50% - 4px);height:auto;aspect-ratio:1}
  .trial-item{grid-template-columns:36px 1fr}
  .cmp-tbl{display:block;overflow-x:auto}
  .fl-bar{padding:8px 16px}
  .fl-bar p{display:none}
  .fl-bar .btn{width:100%;justify-content:center}
  .sub-hero h1{font-size:24px}
  .ttl{font-size:22px}
  .cta-band h2{font-size:18px}
}